Journal issues > Issue 3, May 2019 > Tumoral melanosis associated with ipilimumab plus nivolumab-treated metastatic melanoma: A case report and review of the literature

Tumoral melanosis associated with ipilimumab plus nivolumab-treated metastatic melanoma: A case report and review of the literature

By: R. De Bock MD, D. Debaere MD, S. Deloose MD, M. Gallant MD, B. Deconinck MD, A. Nollet MD

SUMMARY

Tumoral melanosis can be a manifestation of completely regressed melanoma that presents as a possibly suspicious pigmented lesion, with histology showing dense infiltration of benign melanophages. This case report describes a unique case of a 32-year-old carpenter diagnosed with a metastasis located at the gastric fundus, three years after primary diagnosis of a malignant melanoma at the right shoulder. Despite the fact that combined immunotherapy with ipilimumab plus nivolumab could only be administered once due to the development of severe colitis grade 2-3, a control gastroscopy after four months reveals macroscopic alteration of the gastric metastasis with histological regression to benign tumoral melanosis.

(BELG J MED ONCOL 2019;13(3):106–109)

To read the full artice you have the following options:

* (only possible for healthcare professionals with RIZIV/INAMI/MATRICULE working in the field of Oncology/Hemato-oncology in Belgium and Luxembourg with prescription authorisation)

Purchase this article for €2.42

** (for healthcare professionals with prescribing authorisation working outside the field of Oncology/Hemato-oncology in Belgium and Luxembourg as well as those without prescribing authorisation working as healthcare professional in Oncology/Hemato-oncology in Belgium and Luxembourg, plus persons without prescription authorisation working outside Belgium and Luxembourg, plus healthcare professionals with prescribing authorisation outside Belgium and Luxembourg plus non-healthcare professionals from outside or inside Belgium or Luxembourg)

Top