Tumoral melanosis associated with ipilimumab plus nivolumab-treated metastatic melanoma: A case report and review of the literature

BJMO - volume 13, issue 3, may 2019

R. De Bock MD, D. Debaere MD, S. Deloose MD, M. Gallant MD, B. Deconinck MD, A. Nollet MD


Tumoral melanosis can be a manifestation of completely regressed melanoma that presents as a possibly suspicious pigmented lesion, with histology showing dense infiltration of benign melanophages. This case report describes a unique case of a 32-year-old carpenter diagnosed with a metastasis located at the gastric fundus, three years after primary diagnosis of a malignant melanoma at the right shoulder. Despite the fact that combined immunotherapy with ipilimumab plus nivolumab could only be administered once due to the development of severe colitis grade 2-3, a control gastroscopy after four months reveals macroscopic alteration of the gastric metastasis with histological regression to benign tumoral melanosis.

(BELG J MED ONCOL 2019;13(3):106–109)

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