On the 23rd and 24th of November 2012, the Jules Bordet Institute and the Belgian Society of Medical Oncology (BSMO) hosted the 6th Belgian symposium on the integration of molecular biology advances into oncology clinical practice. The aim of this meeting once more was to translate the major advances made in molecular and biological understanding in cancer into clear messages for daily oncological, clinical practice. Over the two days, a plethora of Belgian and international key opinion leaders discussed the clinical impact of molecular advances in several tumour types. Given the high quality of the different lectures, it was not surprising to see that the meeting again obtained the ESMO label. (BELG J MED ONCOL 2012;6:207–211)