BJMO - volume 13, issue 2, march 2019
A. Hébrant PhD, K. Punie MD, PhD, F.P. Duhoux MD, PhD, C. Colpaert MD, PhD, G. Floris MD, PhD, K. Lambein MD, PhD, P. Neven MD, PhD, M. Berlière MD, PhD, R. Salgado MD, PhD, M. Chintinne MD, PhD, K. Dahan MD, PhD, S. Dedeurwaerdere MD, J. De Grève MD, PhD, A. de Leener MD, PhD, H. Denys MD, PhD, R. de Putter MD, PhD, L. Desmyter PhD, M. Baldewijns MD, PhD, D. Feret MD, C. Fontaine MD, C. Galant MD, PhD, P. Hilbert PhD, J. Janssens MD, PhD, D. Larsimont MD, PhD, P. Lefesvre MD, PhD, T. Sticca PhD, M-D. Tkint de Roodenbeke MD, G. Van Den Eynden MD, PhD, I. Vanden Bempt PhD, C. Van den Broecke MD, I. Vandernoot MD, C. Sotiriou MD, PhD, J. van Dorpe MD, PhD, H.A. Poirel MD, PhD, E. Van Valckenborgh PhD, G. Raicevic PhD, M. Van den Bulcke PhD, P. Aftimos MD
In order to advise the Federal Government on all matters related to personalised medicine in oncology, including the reimbursement of molecular tests, the Commission of Personalized Medicine (ComPerMed) has applied, for the breast tumours, the same methodology as previously applied for the digestive tumours. Meaning, the different molecular tests, represented in the shape of algorithms, are annotated with test levels — which aim to reflect their relevance based on current available data and to define the reimbursement — and are documented with recent literature, guidelines and a brief technical description.
(BELG J MED ONCOL 2019;13(2):40–45)
Read moreBJMO - volume 12, issue 4, august 2018
F.P. Duhoux MD, PhD
At ASCO 2018, the results of several anticipated studies were presented. While most of these studies were thought provoking, many results left practicing oncologists a little bit disoriented. How to translate these data in clinical practice?
Read moreBJMO - 12, issue 3, february 2018
F.P. Duhoux MD, PhD
In his presentation, professor François Duhoux (Cliniques Universitaires St. Luc, Brussels) gave an overview of the key messages from the 2017 San Antonio Breast Cancer Symposium. Four main topics were addressed: dose dense adjuvant chemotherapy, chemotherapy for patients with lobular disease, optimizing hormonal therapy for younger breast cancer patients and the optimal duration of endocrine therapy.
Read moreBJMO - volume 12, issue 1, february 2018
D. Verhoeven MD, PhD, F.P. Duhoux MD, PhD, E. de Azambuja MD, PhD, H. Wildiers MD, PhD, P. Vuylsteke MD, A. Barbeaux MD, N. van Damme , E. Van Eycken MD
Limited literature is available about quality management in systemic treatment of breast cancer patients. Professionals are the key players in the identification and interpretation of quality indicators. The Belgian Society of Medical Oncology takes the lead in the field of quality management of systemic treatment for cancer, especially breast cancer. A narrow collaboration with the Belgian Cancer Registry will allow benchmarking. The results will be presented and discussed between peers of the society. This should lead to better outcomes for all Belgian centres. All Belgian Society of Medical Oncology members are called for active participation
(BELG J MED ONCOL 2018;12(1):15–21)
Read moreBJMO - volume 12, issue 1, february 2018
C. van Marcke MD, L. Renard MD, F.P. Duhoux MD, PhD
Patients with HER2-positive advanced breast cancer frequently develop brain metastases. Dual anti-HER2 therapy significantly prolongs survival in previously untreated metastatic disease. However, no safety data exist on the concurrent use of pertuzumab, trastuzumab and brain radiotherapy. We describe two cases of previously untreated HER2-positive breast cancer and brain metastases, who developed acute cerebral toxicity during the concomitant administration of anti-HER2 therapy and whole-brain radiotherapy. Systematic clinical data is warranted to prove the safety of this association.
(BELG J MED ONCOL 2018;12(1):22–25)
Read moreBJMO - volume 11, issue 8, december 2017
H. Wildiers MD, PhD, F.P. Duhoux MD, PhD, A. Awada MD, PhD, E. de Azambuja MD, PhD
Since the publication from the Belgian Society of Medical Oncology breast cancer task force in 2014 in the Belgian Journal of Medical Oncology, new information has become available on optimal chemotherapy regimens for early breast cancer patients. On February 24th, 2017, 37 medical oncologists involved in breast cancer management reviewed the most important scientific data on this topic. The authors of this paper summarised the findings, and sent a questionnaire to the members asking for their input. This paper summarises the consensus of this exercise.
(BELG J MED ONCOL 2017;11(8):375–379)
Read moreBJMO - volume 11, issue 5, september 2017
L. Lallemand , F.P. Duhoux MD, PhD
Dysregulation of the cell cycle, especially in the cyclin D-cyclin dependent kinase (CDK) pathway, is a key component of carcinogenesis, also in breast cancer. Cyclin dependent kinase inhibition has emerged as an attractive targeted cancer therapy. Recently, three oral agents selectively targeting CDK 4/6 have been developed for the treatment of breast cancer: palbociclib (PD 0332991), ribociclib (LEE011), and abemaciclib (LY2835219). Clinical trials have shown an improvement in progression-free survival when palbociclib and ribociclib are used in combination with endocrine therapy. The next wave of studies will examine the efficacy of CDK 4/6 inhibitors in combination with other targeted therapies, in the (neo)-adjuvant situation, and in other breast cancer subtypes, such as HER2 positive breast cancer. Palbociclib and ribociclib recently received accelerated Food and Drug Administration approval for the treatment of hormone receptor positive advanced breast cancer in combination with endocrine therapy. This combination has become the new standard of care for the treatment of patients with hormone receptor positive breast cancer.
(BELG J MED ONCOL 2017;11(5):234–241)
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