BJMO - volume 10, issue 2, april 2016
E. De Vlieghere PhD
Summary
The peritoneal tumour-environment plays an important role in the adhesion of disseminated cancer cells into the peritoneal wall. Disseminated cancer cells can be deceived to adhere to an ecological trap instead of the peritoneal wall through biomimetics of the peritoneal tumour-environment. Encapsulated carcinoma associated fibroblasts trap free cancer cells in the peritoneal space. Removal of the traps results in a delay of tumour formation and a prolonged survival in mouse models.
(BELG J MED ONCOL 2016;10(2):73–75)
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