Evans blue as a diagnostic tool for non-muscle-invasive bladder cancer: a preclinical study

BJMO - volume 10, issue 7, november 2016

S. Elsen PhD, E. Lerut MD, PhD, B. Van Cleynenbreugel MD, PhD, F. Van der Aa MD, PhD, H. Van Poppel MD, PhD, P.A. de Witte PhD


The diagnosis of non-muscle-invasive bladder cancer using the standard white-light cystoscopy technique is not optimal and leads to underdiagnosis of some of the tumours. Therefore, in this thesis, the use of Evans blue dye as a diagnostic tool to aid bladder cancer detection during white-light cystoscopy was investigated using a rat orthotopic bladder cancer model. The results show that Evans blue might have great potential to assist detection of bladder cancer in a clinical setting.

(BELG J MED ONCOL 2016;10(7):281–284)

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BRCA2 gene mutation and risk of aggressive prostate cancer

BJMO - volume 10, issue 6, september 2016

F. Baekelandt MD, W. Everaerts MD, PhD, M. Albersen MD, PhD, B. Van Cleynenbreugel MD, PhD, U. Milenkovic MD, C. Assenmacher MD, S. Joniau MD, PhD


BRCA2 mutation carriers generally present with prostate cancer at a younger age, with more aggressive disease and with a higher risk of nodal involvement or distant metastases at diagnosis. We present a patient with metastatic castrate resistant prostate cancer with a BRCA2 gene mutation and its clinical significance for daily practice.

(BELG J MED ONCOL 2016;10(6):223–227)

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Diagnosis and management of urogenital schistosomiasis in a young adult; a case report

BJMO - volume 6, issue 3, june 2012

G. De Win , T. Van den Broeck , B. Van Cleynenbreugel MD, PhD, F. Claus , E. Lerut MD, PhD

Schistosomiasis is rarely diagnosed in Western European countries. However, due to the popularity of exotic vacations, more and more western patients can get infected by schistosomiasis. Awareness of this disease is important, as an infection can lead to non-transitional cell bladder carcinoma in the long run (squamous cell carcinoma; SCC). In this article, we present a rare case of urogenital schistosomiasis in a 27-year old Belgian male. Extensive patient history together with eosinophil count and bladder biopsy, is the key to making the diagnosis. Medical treatment with praziquantel is often sufficient. (BELG J MED ONCOL 2012;6:97–101)

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