The biology and role of epithelial to mesenchymal transition in solid tumours

BJMO - volume 6, issue 1, february 2012

A. Stoyianni MD, PhD, G. Pentheroudakis MD, PhD, N. Pavlidis MD, PhD

Epithelial-mesenchymal transitions (EMT) occur as key steps during embryonic morphogenesis and are now implicated in the progression of primary tumours towards metastases, but also towards the accumulation of stem-cell properties. Recent advances have fostered a more detailed understanding of molecular mechanisms and networks governing EMT and leading to more dedifferentiated and malignant states. Owing to the clinical importance of the EMT-induced processes, inhibition of EMT is an attractive therapeutic approach that could have significant effect on disease outcome.

(BELG J MED ONCOL 2012;6:3–12)

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